Navigating the complexities of bilayer tablet manufacturing
Bilayer tablets have gained prominence as a sophisticated oral drug delivery system, offering a versatile approach to managing complex therapeutic needs. By combining two distinct layers within a single dosage form, these tablets allow for the co-administration of drugs with differing release profiles or chemically incompatible properties.
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Overcoming key pharmaceutical formulation challenges with liquid-filled hard capsules
Liquid-filled capsules are an innovative drug delivery system, particularly valuable for pharmaceuticals with challenging formulation requirements. These capsules can enhance bioavailability, improve dosing accuracy and product stability making them an effective solution for a range of formulation issues. This article explores common formulation challenges that liquid-filled capsules address and discusses critical considerations for formulating these capsule products.
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Should you bottle it up or blister it?
Pharmaceutical packaging for oral solids plays a critical role in ensuring product integrity and safety. Traditionally, bottles have been the primary choice for packaging tablets and capsules. However, the past few decades have seen blister packaging emerge as a strong alternative, particularly for its suitability for unit-dose products. While both bottles and blister packs offer unique benefits, blister packaging provides significant advantages in terms of product protection, patient compliance, and cost effectiveness. Here, we’ll explore why blister packaging is often the superior choice over bottles, focusing on quality, patient safety, regulatory compliance, and overall cost-effectiveness.
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Optimising investment in hot-melt granulation the smart way
Hot-melt granulation has emerged as a transformative process in pharmaceutical manufacturing, offering distinct advantages over conventional wet and dry granulation techniques. Recent technological advancements in equipment design and the growing emphasis on continuous manufacturing have further expanded the application scope of melt granulation.
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